Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment
نویسندگان
چکیده
منابع مشابه
Rheb and Rags come together at the lysosome to activate mTORC1.
mTORC1 (mammalian target of rampamycin complex 1) is a highly conserved protein complex regulating cell growth and metabolism via its kinase mTOR (mammalian target of rapamycin). The activity of mTOR is under the control of various GTPases, of which Rheb and the Rags play a central role. The presence of amino acids is a strict requirement for mTORC1 activity. The heterodimeric Rag GTPases local...
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Ras homolog enriched in brain (Rheb) is a small GTPase that regulates cell growth, differentiation, and survival by upregulating mammalian target of rapamycin complex 1 (mTORC1) signaling. The role of Rheb/mTORC1 signaling in the activation of kidney fibroblasts and the development of kidney fibrosis remains largely unknown. In this study, we found that Rheb/mTORC1 signaling was activated in in...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2019
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e19-03-0146